Sheep anti Human Vesicle Associated Membrane Protein (VAMP 1/2)
Catalog number: K105P| Isotype | IgG |
| Product Type |
Polyclonal Antibody |
| Units | 250 µg |
| Host | Sheep |
| Species Reactivity |
Human Rat |
| Application |
Immunoprecipitation Western Blotting |
Background
Vesicle-associated membrane protein 2 is essential for cAMP-regulated exocytosis. VAMP (also know as synaptobrevin) is part of the synaptic vesicle docking and fusion complex and plays a central role in neuroexocytosis. Two VAMP (vesicle-associated membrane protein) isoforms are expressed in the nervous system and are differently distributed among the specialized parts of the tissue. VAMP-1 and -2 are present in all tissues tested, including kidney, adrenal gland, liver, pancreas, thyroid, heart, and smooth muscle. The two isoforms are differentially expressed in various tissues and their level may depend on differentiation. VAMP-1 is restricted to exocrine pancreas and to kidney tubular cells, whereas VAMP-2 is the predominant isoform present in Langerhans islets and in glomerular cells. Both isoforms show a patchy vesicular intracellular distribution in confocal microscopy. Evidence for the importance of neuronal VAMPproteins in the physiology of all cells is indicated.
Synonyms: Sheep anti vesicle associated membrane protein 1 and 2, VAMP 1 and 2, VAMP1/2, VAMP 1/2, VAMP-1/2; Synaptobrevin 1 and 2
Source
Immunogen: Full length VAMP1/2 protein
Product
Product Form: Unconjugated
Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide
Purification Method: Ammonium Sulfate Precipitation
Concentration: See vial for concentration
Applications
Applications: Western Blotting, Immunoprecipitation
Functional Analysis: Western Blotting
Storage
Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
Product Stability: See expiration date on vial
Shipping Conditions: Room Temperature
Caution
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. It may contain hazardous ingredients. Please refer to the Safety Data Sheets (SDS) for additional information and proper handling procedures. Dispose product remainders according to local regulations.This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
References
1. Moreno, J.A., et al. Sustained translational repression by eIF2α-P mediates prion neurodegeneration. Nature (2012), 485, 507-511
Protein Reference(s)
Database Name: UniProt
Accession Number: O35619 VAMP-1 P19065 VAMP-2
Safety Datasheet(s) for this product:
| NM_Sodium Azide |