Catalogue
Sheep anti-Cytochrome C
Catalog number: A195P| Clone | Polyclonal |
| Product Type |
Primary Antibodies |
| Units | 200 µl |
| Host | Sheep |
| Species Reactivity |
Dog Human Rabbit Rat |
| Application |
Immunohistochemistry Immunoprecipitation Western Blotting |
Background
Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. Defects in CYCS are the cause of thrombocytopenia type 4 (THC4) also known as autosomal dominant thrombocytopenia type 4. Thrombocytopenia is the presence of relatively few platelets in blood. THC4 is a non-syndromic form of thrombocytopenia. Clinical manifestations of thrombocytopenia are absent or mild. THC4 may be caused by dysregulated platelet formation.
Source
Immunogen: Full length recombinant Cytochrome
Product
Whole sheep antiserum, no carrier or preservative added.
Formulation: Whole sheep antiserum, no carrier or preservative added.
Purification Method: Whole Antiserum, no purification
Applications
Western Blot|Immunoprecipitation|Immunohistochemistry
Positive Control: Rat1 cell line; Mitochondrion matrix
Storage
Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
Caution
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. It may contain hazardous ingredients. Please refer to the Safety Data Sheets (SDS) for additional information and proper handling procedures. Dispose product remainders according to local regulations.This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
Protein Reference(s)
Database Name: UniProt
Accession Number: P00011 (Canine), P00008 (Rabbit), P62898 (Rat), P9
Species Accession: Human, Rat