Catalogue
Rabbit anti Human S100P-Binding Protein
Catalog number: X2757P| Isotype | IgG |
| Product Type |
Antigen Immunoaffinity Purified Polyclonal |
| Units | 100 µg |
| Host | Rabbit |
| Species Reactivity |
Human |
| Application |
Enzyme Immunoassay Immunohistochemistry Western Blotting |
Background
The function of this binding protein is not fully known. It is known to interact with the S100P and colocalizes with S100P in the nucleus. S100P may stimulate cell proliferation in an autocrine manner via activation of the receptor for activated glycation end products (RAGE). Expressed in brain, spleen, and lung. Not detected in pancreas or liver. In pancreas, expressed predominantly in islet cells and to a lesser extent in acinar cells, but not expressed in ductal cells. Up-regulated in various pancreatic ductal adenocarcinomas and pancreatic intraepithelial neoplasias. Detected in pancreatic ductal adenocarcinoma cells (at protein level). Not detected in non-neoplastic ductal epithelium (at protein level).
Synonyms: S100PBP
Source
Immunogen: Synthetic peptide derived from human S100P-binding protein.
Product
Product Form: Affinity Purified
Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide
Purification Method: Antigen Immunoaffiinity Purification
Concentration: See vial for concentration
Applications
Optimal concentration should be evaluated by serial dilutions.
Functional Analysis: Western Blotting
Storage
Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
Product Stability: See expiration date on vial
Shipping Conditions: Ship at ambient temperature, freeze upon arrival
Caution
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. It may contain hazardous ingredients. Please refer to the Safety Data Sheets (SDS) for additional information and proper handling procedures. Dispose product remainders according to local regulations.This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
References
1. Dowen, S.E., et al. ‘Expression of S100P and its novel binding partner S100PBPR in early pancreatic cancer.’ Am. J. Pathol., 166, 81-92 (2005)
2. Deng, H., et al. ‘Usefulness of S100P in diagnosis of adenocarcinoma of pancreas on fine-needle aspiration biopsy specimens.’ Am. J. Clin. Pathol., 129, 81-88 (2008)
Protein Reference(s)
Database Name: SwissProt
Accession Number: Q96BU1
Species Accession: Human
Safety Datasheet(s) for this product:
| NM_Sodium Azide |