Catalogue

Background
Caveolin 1 is a tyrosine phosphoprotein that plays an essential role in the formation of caveolae where it acts as a scaffolding protein. It has also been shown to bind cholesterol and to be involved in the lipid transport, membrane trafficking and signal transduction. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.

Source

Immunogen: Synthetic peptide derived from the human caveolin-1 beta isoform

Product

Product Form: Unconjugated

Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide

Purification Method: Ammonium Sulfate Precipitation

Concentration: See vial for concentration

Applications
Antibody can be used for Western blotting (1-5 µg/ml). Optimal concentration should be evaluated by serial dilutions.

Functional Analysis: Western Blotting

Storage
Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Product Stability: See expiration date on vial

Shipping Conditions: Ship at ambient temperature, freeze upon arrival

Caution
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. It may contain hazardous ingredients. Please refer to the Safety Data Sheets (SDS) for additional information and proper handling procedures. Dispose product remainders according to local regulations.This datasheet is as accurate as reasonably achievable, but Nordic-MUbio​ accepts no liability for any inaccuracies or omissions in this information.

References
1. Cai, T., et al. 'Regulation of caveolin-1 membrane trafficking by the Na/K-ATPase.' J. Cell Biol. 2008, 182, 1153-1169. 2. Dittman, K., et al. 'Radiation-induced caveolin-1 associated EGFR internalization is linked with nuclear EGFR transport and activation of DNA-PK.' Mol. Cancer 2008, 7, 69. 3. Zhong, Y., et al. 'Caveolin-1 regulates human immunodeficiency virus-1 Tat-induced alterations of tight junction protein expression via modulation of the Ras signaling.' J. Neurosci. 2008, 28, 7788-7796. 4. Tourkina, E., et al. 'Antifibrotic properties of caveolin-1 scaffolding domain in vitro and in vivo.' Am. J. Physiol. Lung Cell. Mol. Physiol. 2008, 294, L843-L861 5. Huang, J.H., et al. 'Identification of the HIV-1 gp41 core-binding motif in the scaffolding domain of caveolin-1.' J. Biol. Chem. 2007, 282, 6143-6152.

Protein Reference(s)

Database Name: UniProt

Accession Number: Q03135

Species Accession: Human

Safety Datasheet(s) for this product: