PhosphotyrosineCatalog number: X1021S
The role of tyrosine phosphorylation in transduction of the mitogenic signal from transmembrane receptors and in transformation by oncogene tyrosine kinases has been the subject of intense investigation for several years. While the phosphorylation of specific tyrosine residues has been shown to be a primary mechanism of signal transduction during normal mitogenesis, cell cycle progression and oncogenic transformation, its role in other areas such as differentiation and gap junction communication, is a matter of active and ongoing research. Antibodies that specifically recognize phosphorylated tyrosine residues have proved to be invaluable to the study of tyrosine -phosphorylated proteins and the biochemical pathways in which they function.
Immunogen: Hybridoma produced from Balb/C mice immunized with phosphotyrosine coupled to carrier protein.
Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide.
Western Blot|Immunoprecipitation|Enzyme Immunoassay|Immunohistochemistry
Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
Shipping Conditions: Ship at ambient temperature, do not freeze, refrigerate upon arrival
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. It may contain hazardous ingredients. Please refer to the Safety Data Sheets (SDS) for additional information and proper handling procedures. Dispose product remainders according to local regulations.This datasheet is as accurate as reasonably achievable, but Exalpha Biologicals accepts no liability for any inaccuracies or omissions in this information.
Safety Datasheet(s) for this product:
|Western blot using X1021S (clone PY20) with A431 control (lane 1) and A431 stimulated with epidermal growth factor (EGF, lane 2). The phosphorylated EGF receptor is visible at 175 kDa in lane 2.|
Western blot using X1021S (clone PY20) with A431 control (lane 1) and A431 stimulated with epidermal growth factor (EGF, lane 2). The phosphorylated EGF receptor is visible at 175 kDa in lane 2.