Catalogue
Monocarboxylate Transport 2
Catalog number: X2372B| Product Type |
Blocking Peptide |
| Units | 50 µg |
| Host | Rabbit |
| Species Reactivity |
Human |
| Application |
Western Blotting |
Background
Functions as a proton-linked monocarboxylate transporter and catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. MCT2 is a very high affinity pyruvate transporter. MCT2 is a cell membrane; Multi-pass membrane protein with high expression in testis, moderate to low expression in spleen, heart, kidney, pancreas, skeletal muscle, brain and leukocytes. The normal expression of MCT2 is restricted to low levels of expression in normal tissues, but is widely expressed in cancer cells.
Synonyms: MCT2; Solute carrier family 16 member 7; SLC16A7
Source
Immunogen: Peptide Immunogen
Product
Product Form: Unconjugated
Formulation: Provided as solution in phosphate buffered saline
Concentration: See vial for concentration
Applications
For use with Monocarboxylate Transport 2 polyclonal antibodies (Cat. No. X2368P & X2371P).
Functional Analysis: Western Blotting
Positive Control: Testis, spleen, heart, kidney, pancreas, skeletal muscle, brain and leukocyte.
Storage
Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
Product Stability: See expiration date on vial
Shipping Conditions: Ship at ambient temperature, freeze upon arrival
Caution
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. It may contain hazardous ingredients. Please refer to the Safety Data Sheets (SDS) for additional information and proper handling procedures. Dispose product remainders according to local regulations.This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
References
1: Dao L., Landschulz W.H., Landschulz K.T.; Cloning of human monocarboxylate transporter 2 (hMCT2). Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases.
2: Lin R.-Y., Vera J.C., Chaganti R.S.K., Golde D.W.;
Human monocarboxylate transporter 2 (MCT2) is a high affinity pyruvate transporter.;
J. Biol. Chem. 273:28959-28965(1998).
Protein Reference(s)
Database Name: UniProt
Accession Number: O60669 (Human)
Species Accession: Human